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Below are the 20 most recent journal entries recorded in
nancygold's LiveJournal:
| Friday, July 11th, 2025 | |
| 12:16 am | You're bald, because your maternal line fucked with degenerates mtDNA Damage Accumulates with Age Mitochondrial DNA is highly exposed to oxidative stress (ROS) and has limited repair mechanisms. In balding scalps: Studies have found mtDNA deletions and mutations. Increased 8-OHdG (a marker of mtDNA oxidative damage) in dermal papilla cells of AGA patients. These cells become senescent, losing their ability to support hair follicles. 3. Mitochondrial Dysfunction = Increased ROS = Hair Loss Excessive reactive oxygen species (ROS) from malfunctioning mitochondria: Trigger apoptosis in follicle-supporting cells. Inhibit Wnt/β-catenin signaling, which is essential for hair growth. Push cells into a fibrotic, aging state. In AGA, there’s a pattern of premature aging and inflammation around miniaturizing follicles. 4. Maternal Inheritance Clues mtDNA is maternally inherited. While baldness is polygenic (many genes, including autosomal and X-linked), some studies have found: Correlation between maternal family history and AGA severity. Suggests mtDNA or mitochondrial factors could contribute. 5. DHT + Mitochondrial Interaction DHT (dihydrotestosterone) sensitivity in AGA affects dermal papilla cells. DHT has been shown to: Downregulate mitochondrial gene expression. Promote mitochondrial fragmentation and cellular stress in hair follicles. This implies that mitochondrial dysfunction may not only be a result of baldness but also a driver when combined with hormonal signals. both microneedling and aggressive scalp massage work on the same fundamental principle: they trigger controlled micro-injury to the scalp, which initiates a regenerative wound-healing response that can reactivate dormant hair follicles. Let’s go deeper into how and why this works — from both a mechanical and molecular standpoint: A. Inflammatory Phase (Days 1–3) Damage signals (DAMPs) activate immune cells. Release of cytokines like IL-6, TNF-α, and IL-1β. Recruitment of macrophages, which clear debris and secrete pro-regenerative factors. B. Proliferation Phase Wnt/β-catenin pathway gets activated — this is crucial for anagen (growth phase) re-entry. Increased fibroblast activity, angiogenesis (new blood vessels), and collagen remodeling. Stimulation of hair follicle stem cells (HFSCs) in the bulge area. C. Mitochondrial and Metabolic Response Cells in the hair follicle shift from quiescent metabolism (glycolysis) to active mitochondrial respiration (OXPHOS). ROS generated by mitochondria act as signaling molecules, not damage, at low levels. Boost in ATP, NAD+, and SIRT1 activity helps drive stem cell proliferation and differentiation. Current Mood:  amusedCurrent Music: Death Keep Soundtrack |
| Tuesday, July 8th, 2025 | |
| 9:01 pm | 1988 D&D was the most progressive  Current Mood: amused |
| Sunday, July 6th, 2025 | |
| 5:55 pm | Ukrainian eats crucified Russian conscript malchik in panties  Current Mood: amused |
| 3:16 pm | Nail Art Air Brush Somehow all our D&D mini painting tools come out of a beauty salon. make up sponges and brushes, nail art brushes and even airbrush: https://www.youtube.com/watch?v=isqaylQ Although most influencers keep promoting expensive car painting airbrushes. They are bulky and noisy, that makes them feel manlier. Then again, manliness is expressed through ugliness.  Current Mood: amused |
| Saturday, July 5th, 2025 | |
| 12:42 pm | A way to roll d20 in prison, on train or during meetings https://constantchaos.itch.io/dicefold Another way is rolling d20 mentally. Without any tool or external source of randomness. Think of two words. Count the letters in both. If second count is even, add the count of 1st to the 10. Otherwise subtract it. Additional rules, If second has 5 letters - result is 10. If second word has less than 5 letters, then the result is 1 Ensure words don't repeat during a session. Obviously it is not very failproof if you are smart. Systems like ChatGPT easily roll 20ies most of the time, making error just once per 20 rolls.  Current Mood: amusedCurrent Music: https://www.youtube.com/watch?v=vxqHIi1UuQo |
| Tuesday, July 1st, 2025 | |
| 11:17 pm | Elmore Minis Somehow I never knew there is a series based of Elmore's artworks. https://www.darkswordminiatures.com/pro The dude did official art for 2e AD&D and Might & Magic games. Elmoer's art is cartoonish HoMM2 style art, which somehow died nowadays in favor of annoying warhammerish slop, or the grimdark demon shits slop. GF9 nine D&D minis were kinda okay, but a bit too realistic for my liking. The fairy tale component is missing. Unfortunately these minis are oldschool metal, so prone to chipped paint and breaking plastic stuff. But yeah, just compare them to the bland modern ones       Current Mood: amused |
| Monday, June 30th, 2025 | |
| 11:45 am | Russian Pigdogs Russians infested Iran long before the 20th century.  Current Mood: amused |
| Monday, June 23rd, 2025 | |
| 9:40 pm |  Current Mood: amused |
| Sunday, June 22nd, 2025 | |
| 3:07 am | My D&D Campaign is clear enough for ChatGPT to run Basically ChatGPT can DM it easily. https://chatgpt.com/share/68575736-5  Current Mood: amused |
| Saturday, June 21st, 2025 | |
| 1:15 pm |  Current Mood: amused |
| Tuesday, June 17th, 2025 | |
| 10:10 pm | Everyone seen the iconic D&D cover What most people don't know that it is a cropped version of the original. Due to Gary Gygax's mild misogyny, he demanded the girl to be removed. Really ironic Gygax himself was replaced by a girl in the end lol. TLDR: the D&D we know and love is the work of Lorraine Williams, who led TSR in the 90ies, gave green light to Forgotten Realms.    Current Mood:  accomplishedCurrent Music: FFVII REMAKE: ガードスコーピオン |
| Saturday, June 14th, 2025 | |
| 11:41 pm | Stay mad, transphobes  |
| 7:07 pm | Curse of Azure Bounds So before Baldur's Gate there was the Avatar Trilogy, which itself was precluded by the Finder's Stone Trilogy, which was the very first D&D book I ever read. Back then on some samizdat A4 print out. These trilogies basically advanced the Forgotten Realms, developing characters like Elminster and Mystra. And then there was the Curse of Azure Bonds game, 80ies Baldur's Gate, based of the 1st trilogy. Its Japanese version made Africans white. That is the funniest part about it. Unfortunately Finder's Stone never got a video game, despite it being the prequel to Baldur's Gate 1. Neither Drizzt books got any games. These BTW were prequels to the Icewind Dale games. I think there was Dark Alliance. But it doesn't replace a proper RPG: https://www.youtube.com/watch?v=ypfILbd    Current Mood: amused |
| Tuesday, June 10th, 2025 | |
| 4:57 pm | Lovely Soundtrack Compared to all other new Tangerine Dream inspired trash.  Current Mood: amused |
| Saturday, June 7th, 2025 | |
| 7:54 pm | Version 0.5 of my D&D Campaign Could be found here https://nancygold.itch.io/edds Work on it taught me a few game design approaches. In particular how complex system could be reflected by simple rules.   Current Mood: amused |
| Friday, June 6th, 2025 | |
| 6:29 pm | Latest ChatGPT debugs the scripts it writes In fact, it solves most tasks I throw at it perfectly, if they are properly states. For example, here I asked ChatGPT to produce a script generating random D&D:AS monsters. And then to adapt a few general D&D monsters missing in the DAS games https://chatgpt.com/share/6843176b-3 Although when you just ask it to generate a DAS monster, it tends to generates overkill, like direbadger with 4HP. In D&D "Dire" animals are basically brutal and aggressive version of normal animals. Useful if your game has hunting sections, since usual Badger wont pose much challenge even to a solo Lv.1 hero. Current Mood: amused |
| Thursday, June 5th, 2025 | |
| 11:07 am | Spirituality If I come to power, my first decree will be to administer a test to all citizens: "Is spirituality important for society? Yes/No?" Those who answered "Yes" will be shot on the spot. I assure you, the problems of humanity will be solved instantly. No one will tell you that you don't need HRT/FFS/SRS, that you need to be bodypositive, that a girl can be a bald ugly and have a beard, that the most important thing is not how you look, but your soul. Wars and bullying will end, even the planetary IQ will increase. And the lands occupied by churches can be turned into parks and business centers. Vote for Nancy! Vote for Progress!  Current Mood:  contemplativeCurrent Music: Kyle Dixon & Michael Stein - Hazmat Suits |
| Wednesday, June 4th, 2025 | |
| 1:37 pm | Armed Trans Girls A few hysterical mass shootings over access to HRT, misgendering and dead naming, and the conservatives themselves will be begging to ban firearms. Wanna help? Take your christian dad's gun and shoot the nastiest bully at your high school! Better yet, ask Joanna Rowling for an autograph with her blood. We can do it, girls!  Current Mood: amusedCurrent Music: Motoi Sakuraba - Never Surrender |
| Wednesday, May 28th, 2025 | |
| 2:26 pm | Why we must support every evil policy in the Russia For example, once capital punishment is reinstated, the next step should be using it indiscriminately: "лес рубят - щепкит летят." Basically, blood libel your neighbor, seed hysteria. Russia and Russians should be seen as ultimate evil.  Current Mood: contemplative |
| Sunday, May 25th, 2025 | |
| 10:18 pm | How to promote wider English use at Donbass region?   Current Mood: contemplativeCurrent Music: Kyle Dixon & Michael Stein - You Have Already Lost |