/** Bellows Custom Menu Styles (Customizer) **/
/* main */
.bellows.bellows-main, .bellows.bellows-main .bellows-menu-item, .bellows.bellows-main .bellows-menu-item .bellows-target { font-family:Arial; }
/* Status: Loaded from Transient */
.comments-link {
display: none;
}
.cmplz-hidden{display:none!important;}
.ctl-bullets-container {
display: block;
position: fixed;
bottom: 0;
height: 100%;
z-index: 1049;
font-weight: normal;
height: 70vh;
overflow-x: hidden;
overflow-y: auto;
margin: 15vh auto;
}
body { background-color:#3b3939 }
.header { background-color:#ffffff }
h1 { font: normal 40px/48px Arial, Helvetica, sans-serif; color:; }
h2 { font: normal 36px/43px Arial, Helvetica, sans-serif; color:#3b3939; }
h3 { font: normal 30px/30px Arial, Helvetica, sans-serif; color:#3b3939; }
h4 { font: normal 26px/31px Arial, Helvetica, sans-serif; color:#3b3939; }
h5 { font: normal 24px/29px Arial, Helvetica, sans-serif; color:#3b3939; }
h6 { font: normal 20px/25px Arial, Helvetica, sans-serif; color:#3b3939; }
body { font-weight: normal;}
.logo_h__txt, .logo_link { font: normal 40px/38px Tahoma, Geneva, sans-serif; color:#363f45; }
.sf-menu > li > a { font: normal 14px/18px Open Sans; color:#3b3939; }
.nav.footer-nav a { font: normal 12px/14px Arial, Helvetica, sans-serif; color:#ffffff; }
/* -- customizazione home page 02/2020 -- */
.posts-grid.facing-unknown li.span12 .thumbnail {
margin: 0 30px 10px 0;
}
.posts-grid.facing-unknown li .thumbnail {
margin: 0 0 10px 0;
}
.posts-grid.facing-unknown {
border-top: 0px solid #f5f5f6;
padding: 8px 0 5px;
}
.posts-grid li {
margin-bottom: 5px;
}
p.excerpt {
margin: 0px;
text-align: left;
}
div.type-page p {
margin: 0px;
}
.banner-wrap {
overflow: hidden;
margin: 0 0 100px;
padding: 0;
}
.banner-wrap:last-of-type {
overflow: hidden;
margin: 0px;
padding: 0;
}
.banner-wrap .featured-thumbnail a {
border: 0px;
}
.banner-wrap h5 {
color: #3e454c;
font: 300 20px/1em 'Open Sans', 'sans-serif';
text-transform: uppercase;
text-align: center;
}
/* --------------------------- */
/* IVAN --------------- */
@media screen and (max-width: 600px) {
.mobile-no {
visibility: hidden;
display: none;
}
.page-id-31946 #content{
padding-top: 10px !important;
}
}
@media screen and (min-width: 601px) {
.desk-no {
visibility: hidden;
display: none;
}
}
body.term-73 article header,
body.term-88 article header{
padding-bottom: 0px;
}
body.term-73 article .post_content,
body.term-88 article .post_content{
padding-bottom: 0px;
}
body.term-73 article .excerpt,
body.term-88 article .excerpt{
margin-bottom: 0px;
}
body.term-73 article .post_meta,
body.term-88 article .post_meta{
border: none;
margin-bottom: 0px;
}
body.term-73 article .post_meta .post_category, body.term-73 article .post_meta .post_comment,body.term-88 article .post_meta .post_category, body.term-88 article .post_meta .post_comment{
display: none;
}
.single-news .title-section{
margin-bottom: 0px;
}
.single-news div[data-motopress-static-file="static/static-title.php"]{
margin-bottom: 40px;
}
.slider_off{
display:none;
}
.thirty_accordions_box .accordion-group {
margin-bottom: 10px;
}
.thirty_accordions_box .accordion-heading {
background-color: #f5f5f5;
padding: 15px 0 15px;
}
.thirty_accordions_box .accordion-heading:hover {
background-color: #DCDEDF
}
.thirty_accordions_box .accordion-heading a {
color: #3b3939;
font: 200 32px/1em 'Open Sans', 'sans-serif';
text-transform: uppercase;
}
.thirty_accordions_box .accordion-heading a:hover {
text-decoration:none;
color: #5f823e;
}
@media (min-width: 1200px){
.im-6to7 .row .span2 {
width: 141px;
}
}
@media (max-width: 767px){
.im-6to7 .row .span2 {
width: 25%;
float: left;
}
}
footer .textwidget {
font: 12px/1.2em "Helvetica Neue", Helvetica, Arial, sans-serif;
}
footer .textwidget p {
margin-bottom: 5px;
}
footer .textwidget p.phone {
margin-top: 20px;
}
footer .textwidget p.envelope {
margin-top: 20px;
}
.nav__primary .sf-menu >li >a {
height: 64.546px !important;
}
.title-box.title-centered .title-box_primary,
.title-box.title-centered .title-box_secondary{
text-align: center;
}
.page-id-203 .posts-grid h5,
.page-id-2254 .posts-grid h5,
.page-id-20877 .posts-grid h5,
.page-id-21421 .posts-grid h5{
text-transform: uppercase;
font: 300 18px/1em 'Open Sans', 'sans-serif';
margin-bottom: 36px;
}
.page-id-203 .posts-grid h5 a,
.page-id-2254 .posts-grid h5 a,
.page-id-20877 .posts-grid h5 a,
.page-id-21421 .posts-grid h5 a
{
color: #3b3939;
}
.page-id-203 .posts-grid h5 a:hover,
.page-id-2254 .posts-grid h5 a:hover,
.page-id-20877 .posts-grid h5 a:hover,
.page-id-21421 .posts-grid h5 a:hover{
text-decoration: none;
color: #5f823e;
}
.title-section .title-header {
margin-top: 30px !important;
}
.news-template-default.single.single-news #page-content p,
.news-template-default.single.single-news #page-content ul li,
.news-template-default.single.single-news #page-content ol li{
font-size: 1.2em;
line-height: 1.8em;
}
/* 30 YEARS PAGES */
.thirty-home-title {
/* margin-top: -70px; */
}
.nav__primary .sf-menu >li#menu-item-23651,
.nav__primary .sf-menu >li#menu-item-23685{
background-color: #8dbf41;
border-left: 1px solid #8dbf41;
}
.nav__primary .sf-menu >li#menu-item-23651 a,
.nav__primary .sf-menu >li#menu-item-23685 a{
color: white;
}
.nav__primary .sf-menu >li#menu-item-23651.current-menu-item,
.nav__primary .sf-menu >li#menu-item-23685.current-menu-item{
background-color: #373f45;
border-left: 1px solid #373f45;
}
.nav__primary .sf-menu >li#menu-item-23651:hover,
.nav__primary .sf-menu >li#menu-item-23685:hover{
border-left: 1px solid #e5e6e6;
}
.nav__primary .sf-menu >li#menu-item-23651:hover a,
.nav__primary .sf-menu >li#menu-item-23685:hover a{
color: #373f45;
}
.nav__primary .sf-menu >li#menu-item-23651 >.sub-menu >.menu-item a:hover,
.nav__primary .sf-menu >li#menu-item-23685 >.sub-menu >.menu-item a:hover{
color: #8dbf41;
}
.nav__primary .sf-menu >li#menu-item-23651 >.sub-menu >.menu-item.current-menu-item a{
color: #8dbf41;
}
/*nuovo organigramma */
.nav__primary .sf-menu >li
{
width: 120px;
}
.nav__primary .sf-menu >li#menu-item-30192
{
width: 196px;
}
.nav__primary .sf-menu >li#menu-item-5177
{
width: 180px;
padding: 0 20px
}
.nav__primary .sf-menu >li#menu-item-21101
{
width: 132px;
}
.nav__primary .sf-menu >li#menu-item-23651{
padding: 0 20px;
}
.nav__primary .sf-menu >li#menu-item-23685{
padding: 0 8px;
}
.nav__primary .sf-menu >li#menu-item-21288{
padding: 0 8px;
}
.nav__primary .sf-menu >li#menu-item-21285{
padding: 0 10px;
}
/* 5x1000 5xMille */
.mille-banner {
margin-top: -80px;
background: silver url("https://www.crs4.it/wp-content/uploads/2022/02/SedePula.CRS4_.01-min.jpg") no-repeat scroll center;
height: 350px;
background-size: cover;
position: relative;
}
.mille-page.mille-banner {
margin-top: -31px;
}
.text-mille{
position: absolute;
bottom: 0;
left: 0;
background-color: rgba(0,0,0,0.55);
padding: 7px 20px;
margin-left: 20px;
margin-bottom: 15px
}
.text-mille h2:first-of-type{
color: white;
font-size: 2.4em;
}
.next-banner {
margin-top: -50px;
background: silver url("https://www.crs4.it/wp-content/uploads/2023/06/next-banner.jpg") no-repeat scroll right top;
height: 350px;
background-size: cover;
position: relative;
}
.covid-banner {
margin-top: -80px;
background: silver url("https://www.crs4.it/wp-content/uploads/2021/01/CRS4againstCOVID19-min-scaled.jpg") no-repeat scroll center;
height: 250px;
background-size: cover;
position: relative;
}
.covid-page.covid-banner {
margin-top: -31px;
}
.text-covid{
position: absolute;
bottom: 0;
left: 0;
background-color: rgba(0,0,0,0.35);
padding: 7px 20px;
margin-left: 20px;
margin-bottom: 15px
}
.text-covid h2:first-of-type{
color: white;
font-size: 2.8em;
}
.text-covid a{
color: #fff;
}
.text-covid:hover{
background-color: rgba(255,255,255,0.5);
}
.text-covid a:hover{
color: #000;
text-decoration: none;
}
.button-covid{
position: absolute;
bottom: 20px;
right: 20px;
}
.single-cool_timeline #content.span8 {
/* width: 1170px; */
}
.single-cool_timeline #sidebar {
padding-top: 0px
}
.post-template-default.single.single-post #sidebar,
.single-cool_timeline #sidebar {
padding-top: 0px
}
.single-cool_timeline #sidebar .menu-item-22860,
.single-cool_timeline #sidebar .menu-item-22546{
background-color: #373f45;
}
.single-cool_timeline #sidebar .menu-item-22860 a,
.single-cool_timeline #sidebar .menu-item-22546 a{
color: white;
}
.single-cool_timeline #sidebar .menu-item-22860:hover,
.single-cool_timeline #sidebar .menu-item-22546:hover{
background-color: #dcdedf;
}
.single-cool_timeline #sidebar .menu-item-22860:hover a,
.single-cool_timeline #sidebar .menu-item-22546:hover a{
color: black;
}
.single-cool_timeline #sidebar > div {
margin-top: 0px
}
#nav_menu-4 li{
width: 100%;
}
.single-cool_timeline .type-cool_timeline p {
font: 200 1.2em/1.6em 'Open Sans', 'sans-serif';
}
.single-cool_timeline .type-cool_timeline p:last-child {
margin-bottom: 80px;
}
.post-template-default.single.single-post #content img.wp-post-image {
float:left;
padding: 0px 20px 10px 0px;
}
.post-template-default .post-author,
.post-template-default .breadcrumb,
.single-cool_timeline .post-author,
.single-cool_timeline .breadcrumb{
display: none;
}
.title-box sup {
text-transform: lowercase !important;
}
.years30-small h2 {
font-size: 32px !important;
margin: 0 !important;
display: block;
}
#main_countedown_1 .element_conteiner {
min-width:70px !important;
}
#main_countedown_1 .time_left {
background-color: #B0CA21 !important;
font: inherit !important;
color: #fff !important;
font-weight: 900 !important;
font-size: 24px !important;
padding-bottom: 20%;
padding-top: 20%;
}
#main_countedown_1 .time_description {
font: inherit !important;
font-size: 12px !important;
color: #000000;
text-transform: uppercase;
font-weight: 100 !important;
}
.animation-logo {
margin: 60px auto;
}
.wpcf7 .wpcf7-form p input[type="tel"]{
margin: 0;
height: 35px;
-webkit-box-sizing: border-box;
-moz-box-sizing: border-box;
box-sizing: border-box;
}
@media (min-width: 1200px){
.row-fluid .next{
margin-left: 30px !important;
padding-right: 30px !important;
}
.row-fluid .next-textarea{
}
}
.page-id-21694 .title-section,
.page-id-21421 .title-section,
.page-id-21469 .title-section,
.page-id-21427 .title-section,
.page-id-21426 .title-section,
.page-id-21425 .title-section,
.page-id-21446 .title-section,
.page-id-21448 .title-section,
.page-id-21450 .title-section,
.page-id-21471 .title-section,
.page-id-22360 .title-section,
.page-id-22362 .title-section,
.page-id-22364 .title-section,
.page-id-22366 .title-section,
.page-id-22656 .title-section,
.page-id-21424 .title-section,
.page-id-22965 .title-section,
.page-id-22822 .title-section,
.page-id-23096 .title-section,
.page-id-21429 .title-section,
.page-id-22835 .title-section,
.page-id-22575 .title-section,
.page-id-24274 .title-section,
.page-id-24276 .title-section,
.page-id-24951 .title-section,
.page-id-24870 .title-section,
.page-id-26625 .title-section,
.page-id-26914 .title-section,
.page-id-26940 .title-section,
.page-id-27991 .title-section,
.page-id-28721 .title-section,
.page-id-29376 .title-section,
.page-id-29732 .title-section,
.page-id-29734 .title-section,
.page-id-29722 .title-section,
.page-id-29725 .title-section,
.page-id-29728 .title-section,
.page-id-29730 .title-section,
.page-id-30423 .title-section,
.page-id-30524 .title-section,
.page-id-30839 .title-section,
.page-id-30859 .title-section,
.page-id-30864 .title-section,
.page-id-30869 .title-section,
.page-id-30856 .title-section,
.page-id-30861 .title-section,
.page-id-30866 .title-section,
.page-id-31080 .title-section,
.page-id-31100 .title-section,
.page-id-31061 .title-section,
.page-id-31184 .title-section,
.page-id-28046 .title-section,
.page-id-31893 .title-section,
.page-id-31946 .title-section,
.page-id-27787 .title-section
{
display: none;
}
.page-id-21694 #content,
.page-id-21421 #content,
.page-id-21469 #content,
.page-id-21427 #content,
.page-id-21426 #content,
.page-id-21425 #content,
.page-id-21446 #content,
.page-id-21448 #content,
.page-id-21450 #content,
.page-id-21471 #content,
.page-id-22360 #content,
.page-id-22362 #content,
.page-id-22364 #content,
.page-id-22366 #content,
.page-id-22656 #content,
.page-id-21424 #content,
.page-id-22965 #content,
.page-id-22822 #content,
.page-id-23096 #content,
.page-id-21429 #content,
.page-id-22835 #content,
.page-id-22575 #content,
.page-id-24274 #content,
.page-id-24276 #content,
.page-id-24951 #content,
.page-id-24870 #content,
.page-id-26625 #content,
.page-id-26914 #content,
.page-id-27991 #content,
.page-id-26940 #content,
.page-id-28721 #content,
.page-id-29376 #content,
.page-id-29732 #content,
.page-id-29734 #content,
.page-id-29722 #content,
.page-id-29725 #content,
.page-id-29728 #content,
.page-id-29730 #content,
.page-id-30423 #content,
.page-id-30524 #content,
.page-id-30839 #content,
.page-id-30869 #content,
.page-id-30859 #content,
.page-id-30864 #content,
.page-id-30856 #content,
.page-id-30861 #content,
.page-id-30866 #content,
.page-id-31080 #content,
.page-id-31100 #content,
.page-id-28046 #content,
.page-id-31893 #content,
.page-id-31946 #content,
.page-id-27787 #content
{
padding-top: 100px;
padding-bottom: 80px;
}
.page-id-29732 #content,
.page-id-29734 #content,
.page-id-29722 #content,
.page-id-29725 #content,
.page-id-29728 #content,
.page-id-29730 #content,
.page-id-30423 #content,
.page-id-30869 #content,
.page-id-30859 #content,
.page-id-30864 #content,
.page-id-30856 #content,
.page-id-30861 #content,
.page-id-30866 #content,
.page-id-31061 #content,
.page-id-31184 #content
{
padding-top: 40px
}
.page-id-29734 #content img{
padding-bottom: 40px;
}
img.next_site.rounded {
width: 150px;
border-radius: 50%;
border: 10px solid #e3e3e3;
}
.next_site .nav-tabs {
border-bottom: 1px solid #6b9a24
}
.next_site .nav-tabs li{
text-transform: uppercase;
font-weight: 700 !important;
font: normal 16px/18px Open Sans;
}
.next_site .nav-tabs li.active a{
background-color: #8dbf41;
color: white;
border-bottom: 1px solid #6b9a24
}
.next_site .plan h3{
text-transform: none;
font-weight: 700 !important;
font: normal 16px/18px Open Sans;
background-color: #e5e6e6;
}
.next_site .plan.highlight h3{
background-color: #8dbf41;
border-color: #6b9a24;
font-weight: 900 !important;
}
.next_site .plan h4{
text-transform: none;
font-weight: 400 !important;
font: normal 14px/18px Open Sans;
color: #373f45;
background-color: #c0c0c0;
}
.next_site .plan.highlight h4{
background-color: #b1d678;
border-color: #6b9a24;
color: white
}
.next-page.covid-page-cta-button.text-center{
text-transform:none
}
.next_site .plan .plan-container .plan-features-row{
text-transform: none;
padding:8px;
font-size: 12px;
line-height: 16px !important;
}
.next_site .plan .plan-container .plan-features-row .small{
font-size: 10px;
line-height: 12px !important;
color: #888;
}
.ngs_site .ngs_top_button {
background: #f0f1f1;
padding: 9px 15px;
border: 1px solid #e5e6e6;
border-top: 8px solid #373f45;
}
.ngs_site .ngs_top_button h1{
text-transform: uppercase;
font-weight: 700 !important;
color: #3b3939;
font: normal 16px/18px Open Sans;
}
.ngs_site .ngs_top_button p {
font-weight: 400 !important;
color: #3b3939;
font: normal 12px/16px Open Sans;
}
.ngs_site .ngs_top_button a {
font-weight: 700 !important;
color: #8dbf41;
font: normal 12px/18px Open Sans;
display: block;
margin: 12px 12px 12px 0px;
}
.row.thirty-header .title-box {
margin: 5px 0 0px;
}
.row.thirty-header .title-box .title-box_primary{
color: #3b3939;
font: 200 54px/1em 'Open Sans', 'sans-serif';
}
.row.thirty-header .title-box .title-box_secondary{
color: #3b3939;
}
.row.thirty-header.thirty-home .title-box .title-box_primary{
text-align: center;
font: 200 40px/1em 'Open Sans', 'sans-serif';
margin-bottom: 50px
}
.row.thirty-header.thirty-home .title-box .title-box_secondary{
text-align: center;
}
.row.thirty-header.thirty-home img{
margin: 30px auto 30px;
}
.row.thirty-well-centered .title-box .title-box_primary{
text-align: center;
font: 200 20px/1em 'Open Sans', 'sans-serif';
margin: 20px 0;
}
.row.thirty-well-centered .title-box .title-box_secondary{
text-align: center;
font: 200 14px/1em 'Open Sans', 'sans-serif';
}
.thirty-menu,
#menu-30years,
#menu-30anni{
padding:0px;
list-style-type: none;
background-color: #f7f7f7;
border-radius: 3px;
margin: 0;
}
#menu-covid-projects-en,
#menu-covid-projects{
padding:0px;
list-style-type: none;
background-color: #f7f7f7;
border-radius: 3px;
margin: 0;
}
.thirty-menu li,
#menu-30years li,
#menu-30anni li{
background-color: #f7f7f7;
float: left;
position: relative;
display: inline-block;
border:none !important;
padding:4px 8px;
transition: all 0.3s ease 0s;
transition-property: all;
transition-duration: 0.3s;
transition-timing-function: ease;
transition-delay: 0s;
}
#menu-covid-projects-en li,
#menu-covid-projects li{
background-color: #f7f7f7;
position: relative;
display: block;
border:none !important;
padding:9px 18px;
transition: all 0.3s ease 0s;
transition-property: all;
transition-duration: 0.3s;
transition-timing-function: ease;
transition-delay: 0s;
}
.page-list.thirty-menu .page_item > a,
#menu-30years .menu-item > a,
#menu-30anni .menu-item > a{
color: black;
text-decoration: none;
text-transform: uppercase;
font: normal 12.5px/18px Open Sans
}
#menu-covid-projects-en .menu-item > a,
#menu-covid-projects .menu-item > a{
color: black;
text-decoration: none;
text-transform: uppercase;
font: bold 15px/18px Open Sans
}
.thirty-menu li:hover,
#menu-30years li:hover,
#menu-30anni li:hover,
#menu-covid-projects li:hover,
#menu-covid-projects-en li:hover{
background-color: #dcdedf;
}
.page-list.thirty-menu .page_item.current_page_item,
#menu-30years .menu-item.current-menu-item,
#menu-30anni .menu-item.current-menu-item,
#menu-covid-projects .menu-item.current-menu-item,
#menu-covid-projects-en .menu-item.current-menu-item{
background-color: #373f45;
}
.page-list.thirty-menu .page_item.current_page_item > a,
#menu-30years .menu-item.current-menu-item > a,
#menu-30anni .menu-item.current-menu-item > a,
#menu-covid-projects .menu-item.current-menu-item > a,
#menu-covid-projects-en .menu-item.current-menu-item > a{
color: #fff
}
.page-list.thirty-menu .page_item.current_page_item:hover,
#menu-30years .menu-item.current-menu-item:hover,
#menu-30anni .menu-item.current-menu-item:hover,
#menu-covid-projects .menu-item.current-menu-item:hover,
#menu-covid-projects-en .menu-item.current-menu-item:hover{
background-color: #373f45;
}
.thirty-menu li a:hover,
#menu-30years li a:hover,
#menu-30anni li a:hover,
#menu-covid-projects li a:hover,
#menu-covid-projects-en li a:hover{
text-decoration: none;
}
#menu-30years .sub-menu,
#menu-30anni .sub-menu{
display: none;
position: absolute;
left: -1px;
width: 200px;
margin-left: 1px;
margin-top: 3.6px;
background-color: #f1f1f1;
}
#menu-30years li:hover > .sub-menu,
#menu-30years li .sub-menu:hover,
#menu-30anni li:hover > .sub-menu,
#menu-30anni li .sub-menu:hover {
visibility: visible;
opacity: 1;
display: block;
}
#menu-30years li .sub-menu li,
#menu-30anni li .sub-menu li{
display: block;
clear: both;
width: 100%;
}
.row.thirty-links ul {
list-style-type: none;
margin: 0;
padding: 0;
overflow: hidden;
}
.row.thirty-links li {
float: left;
background-color: #f0f1f1;
transition: all 0.3s ease 0s;
transition-property: all;
transition-duration: 0.3s;
transition-timing-function: ease;
transition-delay: 0s;
}
.row.thirty-links .hr {
margin: 10px 0;
}
.row.thirty-links li a {
display: block;
color: #3b3939;
text-align: center;
padding: 5px 15px;
text-decoration: none;
text-transform: uppercase;
font: normal 14px/18px Open Sans;
}
.row.thirty-links li:hover {
background-color: #dcdedf;
}
.row.thirty-links li a:hover {
text-decoration: none;
}
.row.thirty-links li.active {
background-color: #373f45;
}
.row.thirty-links li.active a {
color: #fff;
}
.row.thirty-title .title-box .title-box_primary{
color: #3b3939;
font: 200 40px/1em 'Open Sans', 'sans-serif';
margin: 30px 0;
}
.cursor-zoomin {
cursor: zoom-in;
}
p.big,
ul.big li,
ol.big li,
.row.thirty-title p{
font: 300 20px/1.5em 'Open Sans', 'sans-serif';
}
p.big a {
font-weight: 400;
}
@media (max-width: 767px){
.row.thirty-header .title-box {
margin: 5px 0 0px;
}
.row.thirty-header .title-box .title-box_primary{
color: #3b3939;
font: 200 40px/1em 'Open Sans', 'sans-serif';
margin: 20px 0;
text-align: center;
}
.row.thirty-header .title-box .title-box_secondary{
color: #3b3939;
text-align: center;
}
.row.thirty-header a img.alignright{
float: none;
margin-bottom: 50px;
}
.row.thirty-links li {
float: none;
}
.row.thirty-title .title-box .title-box_primary {
font: 200 28px/1em 'Open Sans', 'sans-serif';
}
.thirty-title iframe {
margin-top: 40px;
}
}
.thirty-logos img {
/* filter: gray;
/* -webkit-filter: grayscale(1);
filter: grayscale(1);
opacity: 0.8; */
}
.thirty-logos img:hover {
/* -webkit-filter: grayscale(0);
filter: none;
opacity: 1; */
}
.thirty-logos .small-logo {
padding: 80px;
}
/* FINE 30 years*/
#loghist {
background-color: white;
border-radius: 10px;
/* padding: 10px; */
color: black;
text-align: center;
margin-top: -50px;
}
#logocrs4footer {
padding-top: 20px;
}
.mille.covid-page-cta {
background-image: url(https://www.crs4.it/wp-content/uploads/2022/03/foto-di-gruppo_©CRS4_2-small-scaled.jpeg);
background-size: cover;
background-repeat: no-repeat;
background-attachment: fixed;
}
.covid-page-cta {
background-image: url(https://www.crs4.it/wp-content/uploads/2021/01/next_crs4_-2.jpg);
background-size: cover;
background-repeat: no-repeat;
background-attachment: fixed;
}
.covid-page-cta .covid-page-filterwhite{
background-color: rgba(0,40,95,0.3);
padding: 30px;
}
.covid-page-cta1.title-box{
margin-bottom: 4px;
}
.covid-page-cta1.title-box .title-box_primary {
font: 500 26px/1em 'Open Sans', 'sans-serif';
color: white;
}
.covid-page-cta2.title-box,
.airport4all-page-cta{
}
.covid-page-cta2.title-box .title-box_primary,
.covid-page-cta2.title-box .title-box_secondary{
margin:0px 15% 12px;
font-weight: 700;
color: white;
}
.covid-page-cta a.btn{
background: #8dbf41;
}
.covid-page-news {
}
.covid-page-news > h2 {
font: 500 27.2px/1em 'Open Sans', 'sans-serif';
text-transform: uppercase;
}
.covid-page-news .owl-wrapper{
display: flex !important;
}
.covid-page-news .owl-item{
background-color: #f7f7f7;
padding: 10px;
margin-right: 15px;
width: 180px !important;
}
.covid-page-news .owl-item:hover{
text-decoration: none;
background-color: #8dbf41;
color:black;
}
.covid-page-news .owl-item .desc h5 {
margin-top: 0px;
margin-bottom: 3px;
}
.covid-page-news .owl-item .desc h5 a{
font: 700 10.8px/1em 'Open Sans', 'sans-serif';
text-transform: uppercase;
}
.covid-page-news .owl-item .desc p{
font: 300 13.6px/1.3em 'Open Sans', 'sans-serif';
}
.covid-page-title.title-box .title-box_secondary {
font: 500 27.2px/1em 'Open Sans', 'sans-serif';
margin: 30px 0px;
}
@media (max-width: 979px) and (min-width: 768px){
#slider-wrapper {
margin-top: 66px;
}
.camera_caption > div > h2{
font-size: 1.8em !important;
padding: 0 150px !important;
font-weight: 600 !important;
}
}
@media (max-width: 767px){
#slider-wrapper {
display: none;
}
}
@media (max-width: 468px) and (min-width: 300px){
.logo .logo_tagline {
float: none;
width: 100%;
margin: 1px 0 0 0;
font: 200 10px/1.2em 'Open Sans', 'sans-serif';
}
}
@media (max-width: 480px){
#lang_sel{
zoom: 0.8;
margin-bottom: -30px;
}
.logo .logo_tagline {
margin-top: 10px;
font-size: 9px
}
.nav.nav__primary.clearfix {
padding-top: 0px
}
.button-covid{
display:none;
}
.covid-banner {
margin-top: 0px;
margin-bottom: 30px;
background: silver url("https://www.crs4.it/wp-content/uploads/2021/01/CRS4againstCOVID19-min-scaled.jpg") no-repeat scroll center;
height: 160px;
background-size: cover;
position: relative;
}
.text-covid {
width: 100%;
margin: 0px 0px 8px;
text-align: center;
}
.text-covid h2:first-of-type {
font-weight: 400;
font-size: 1.3em;
text-align: center;
}
.thirty-home-title {
/*margin-top: -50px;*/
}
.logo.pull-left {
margin: 0;
padding: 0;
}
.logo img{
width: 35%;
margin-right: 10px
}
.logo p {
}
#menu-30years li:last-child,
#menu-30anni li:last-child{
margin-bottom: 40px;
}
.thirty-menu li,
#menu-30years li,
#menu-30anni li{
width: 100%;
}
#menu-30years .sub-menu,
#menu-30anni .sub-menu{
display: block;
visibility: visible;
opacity: 1;
display: block;
}
#menu-30years .sub-menu,
#menu-30anni .sub-menu{
display: block;
visibility: visible;
opacity: 1;
display: block;
position: relative;
background-color: transparent;
}
#menu-30years .sub-menu li,
#menu-30anni .sub-menu li{
display: block;
visibility: visible;
opacity: 1;
display: block;
position: relative;
background-color: transparent;
}
#menu-30years .current-menu-item .sub-menu li a,
#menu-30anni .current-menu-item .sub-menu li a{
color: white;
}
#menu-30years .sub-menu li a:before,
#menu-30anni .sub-menu li a:before{
content: "- ";
}
#menu-30years .sub-menu li:last-child,
#menu-30anni .sub-menu li:last-child{
margin-bottom: 0px;
}
.title-box .title-box_secondary {
font-size: 16px;
}
#loghist {
margin-top: 10px;
}
}
#nav_menu-3 h4:lang(it)::before{
content: "Ricerca e Sviluppo";
}
#nav_menu-3 h4:lang(en)::before{
content: "R&D Shortcuts";
}
#general_info h4:lang(it)::before{
content: "Informazioni generali";
}
#general_info h4:lang(en)::before{
content: "General Info";
}
.ctl-bullets-container{
/* display: none !important;*/
}
table.datacenter-table {
border:2px solid #666
}
table.datacenter-table th,
table.datacenter-table td{
border:1px solid #666;
padding: 8px 15px
}
table.datacenter-table th{
background-color: #7cb632;
color: white;
padding: 8px 5px
}
#wpcf7-f26913-p26914-o1 .input-btn.btn.btn-from-top,
#wpcf7-f26913-p26940-o1 .input-btn.btn.btn-from-top{
padding: 0;
}
#wpcf7-f26913-p26914-o1 .input-btn.btn.btn-from-top input,
#wpcf7-f26913-p26940-o1 .input-btn.btn.btn-from-top input{
padding: 15px 50px;
height: auto;
}
#wpcf7-f26913-p26914-o1 .input-btn.btn.btn-from-top .ajax-loader,
#wpcf7-f26913-p26940-o1 .input-btn.btn.btn-from-top .ajax-loader{
display: none;
}
#wpcf7-f26913-p26914-o1 form.sent .wpcf7-response-output,
#wpcf7-f26913-p26940-o1 form.sent .wpcf7-response-output{
border: 1px solid #46b450 !important;
background-color: #c1efc5;
color: #0d3503;
font-size: 24px;
line-height: 32px;
padding: 28px !important;
}
#wpcf7-f26913-p26914-o1 form.invalid .wpcf7-response-output,
#wpcf7-f26913-p26940-o1 form.invalid .wpcf7-response-output{
font-size: 20px;
line-height: 32px;
padding: 18px !important;
}
/********************************/
/********************************/
/* font awesome v5 Icon Footer */
.contacts p.home:before {
font-family: "Font Awesome 5 Free";
font-weight: 900;
content: "\f015" !important;
}
.contacts p.phone::before {
font-family: "Font Awesome 5 Free";
font-weight: 900;
content: "\f879" !important;
}
.contacts p.envelope:before {
font-family: "Font Awesome 5 Free";
font-weight: 900;
content: '\f0e0' !important;
}
#back-top-wrapper #back-top a span::after {
font-family: "Font Awesome 5 Free";
content: "\f35b";
font-weight: 900;
position: absolute;
left: 50%;
top: 50%;
margin: -8px 0px 0px -6px !important;
}
/*******************************/
/* fonts opensans by google */
/* open-sans-300 - latin */
@font-face {
font-family: 'Open Sans';
font-style: normal;
font-weight: 300;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-regular - latin */
@font-face {
font-family: 'Open Sans';
font-style: normal;
font-weight: 400;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-regular.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-regular.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-regular.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-regular.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-regular.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-regular.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-500 - latin */
@font-face {
font-family: 'Open Sans';
font-style: normal;
font-weight: 500;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-600 - latin */
@font-face {
font-family: 'Open Sans';
font-style: normal;
font-weight: 600;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-700 - latin */
@font-face {
font-family: 'Open Sans';
font-style: normal;
font-weight: 700;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-700.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-700.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-700.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-700.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-700.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-700.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-800 - latin */
@font-face {
font-family: 'Open Sans';
font-style: normal;
font-weight: 800;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-300italic - latin */
@font-face {
font-family: 'Open Sans';
font-style: italic;
font-weight: 300;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300italic.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300italic.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300italic.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300italic.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300italic.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-300italic.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-italic - latin */
@font-face {
font-family: 'Open Sans';
font-style: italic;
font-weight: 400;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-italic.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-italic.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-italic.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-italic.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-italic.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-italic.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-500italic - latin */
@font-face {
font-family: 'Open Sans';
font-style: italic;
font-weight: 500;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500italic.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500italic.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500italic.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500italic.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500italic.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-500italic.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-600italic - latin */
@font-face {
font-family: 'Open Sans';
font-style: italic;
font-weight: 600;
src: url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600italic.eot'); /* IE9 Compat Modes */
src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600italic.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600italic.woff2') format('woff2'), /* Super Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600italic.woff') format('woff'), /* Modern Browsers */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600italic.ttf') format('truetype'), /* Safari, Android, iOS */
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-600italic.svg#OpenSans') format('svg'); /* Legacy iOS */
}
/* open-sans-700italic - latin */
@font-face {
font-family: 'Open Sans';
font-style: italic;
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src: local(''),
url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800italic.eot?#iefix') format('embedded-opentype'), /* IE6-IE8 */
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url('/wp-content/themes/theme49466/fonts/open-sans-v29-latin/open-sans-v29-latin-800italic.ttf') format('truetype'), /* Safari, Android, iOS */
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/* Enter Your Custom CSS Here */
/* CARLO */
.pub-thumb {
width: 100px;
height: 75px;
}
.pub-thumb, .proj-thumb {
display: block;
/* width: 100px;
height: 75px; */
max-width: 100px;
max-height: 75px;
border-radius: 0.65em;
padding: 0.1em;
}
.pub-year, .project-status {
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padding-bottom: 5px;
}
.row-pub-container, .row-proj-container { padding-bottom: 0.9em;
}
.row-pub-container > div.span2, .row-proj-container > div.span2 { width: 115px;
}
.pub-authors { font-size: 0.9em; }
.pub-journal { font-size: 0.75em; padding-right: 10px; }
.pub-doi { font-size: 0.75em; padding-right: 10px; }
.pub-volume { font-size: 0.75em; padding-right: 10px; }
.pub-publisher { font-size: 0.75em; padding-right: 10px; }
.pub-number { font-size: 0.75em; padding-right: 10px; }
.row-well { padding: 10px; }
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.proj-acronym, .proj-funder, .proj-dates {font-size: 0.9em;}
.proj-groups {font-size: 0.9em;}
.waiting-class { background-image: url("/wp-content/themes/theme49466/images/infinite-loading.gif");
background-repeat: no-repeat;
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background-position: center;
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}
span.proj-boldify, p.boldify { font-weight: bold;}
.thumb-very-small-people {
display: block;
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height: 70px;
/* width: 90px;
height: 90px; */
border-radius: 0.6em;
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}
.thumb-small-people {
display: block;
width: 120px;
height: 120px;
/* width: 90px;
height: 90px; */
border-radius: 0.7em;
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}
.thumb-people {
display: block;
width: 180px;
height: 180px;
border-radius: 0.8em;
padding: 0.1em;
}
.thumb-project {
display: block;
max-width: 120px;
/* height: 120px; */
max-height: 90px;
border-radius: 0.5em;
padding: 0.1em;
}
.single-people-pad {
padding-top: 21px;
}
div.users-block-list p{
color: #363f45;
}
div.people-list div.span2 {
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height: 10.5em;
width: 7.5em;
}
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font-size: 0.9em;
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.users-list-item > a > p {
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.users-list-item > .span3 {
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.users-block-list > a > p > small {
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#bsearchresults h1.page-title {
/* margin-bottom: 1.1em; */
}
#bsearchresults .bsearch_nav {
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div.results-block {
margin-bottom: 1.8em;
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div.results-block hr {
margin: 15px;
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#people-index-container div.well, div.pub-container div.well, div.proj-container div.well {
background-color: transparent;
border: none;
box-shadow: none;
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.abstract-tab, .contacts-tab, .positions-tab, .groups-tab {
padding-bottom: 20px;
}
.contacts-tab h5, .positions-tab h5, .groups-tab h5 {
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padding-bottom: 5px;
}
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.proj-table {
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div.project-data { padding-top: 47px;
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div.project-data > p { margin-bottom: 17px;
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div.people-index .btn:hover,
div.people-index .reply a:hover,
div.people-index .btn:active,
div.people-index .reply a:hover { color: black;
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.proj-table {
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.proj-table tr > th {
border-bottom: 1px solid;
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div.project-data { padding-top: 47px;
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div.project-data > p { margin-bottom: 17px;
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div.people-index .btn:hover,
div.people-index .reply a:hover,
div.people-index .btn:active,
div.people-index .reply a:hover { color: black;
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font-weight: 400;
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border-bottom-right-radius:4px;
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.underlined {
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.authors {
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.space5{
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ul.nooz-list > li > time {
/* margin-right: 15px; */
display: block;
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ul.nooz-list > li {
margin-bottom: 10px;
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@media (max-width: 767px) {
#people-index-container [class*="span"] {
float: left;
margin-left: 20px;
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#people-index-container .span12 {
/*margin-right: 20px; */
width: 95%;
}
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@media (max-width: 420px) {
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.users-block-list {
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@media (max-width: 319px) {
#people-index-container [class*="span"] {
float: none;
margin-left: 0px;
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}
#ecl-notice {
border-top: 2px dashed yellowgreen;
}
/* ******************************************* */
/* PERSONALIZZAZIONI AD PERSONAM */
div.pub-tab-user-luigi-filippini,
div.proj-tab-user-luigi-filippini {
display: none;
}
/* *************************************** */
/* PERSONALIZZAZIONE GUESTBOOK */
#gwolle_gb_write_button .btn-default:hover {
background-color: brown;
border-color: brown;
}
/* ********************************* */
/* se menu su due righe bisogna abbassare i titoli */
.title-section {
margin: 40px 0;
padding: 30px 0 3px;
position: relative;
}
Ospedali e IRCCS
Soluzioni NGS per ottimizzare i processi: scopri i vantaggi di collaborare con noi! Contattaci per una partnership »
Ricerca e Sviluppo
Lavoriamo su progetti di ricerca, fornendo supporto in tutte le fasi. Scopri i nostri servizi »
AZIENDE
Soluzioni NGS personalizzate per la tua azienda (agroalimentare, zoologica, biotecnologica, ...). Contattaci »
Next Generation Sequencing Core
NEXT è una moderna infrastruttura NGS di eccellenza, composta da un Laboratorio, che consente esperimenti di sequenziamento ad alto rendimento , grazie al basso costo e a un elevato livello produttivo, abbinato a un Centro di calcolo di grandi dimensioni (8000+ cores HPC Cluster con 4PB storage). Un’infrastruttura, unica in Italia, progettata per supportare l'elaborazione, la riproducibilità, la tracciabilità e l’archiviazione di dati per la biologia su larga scala .
NEXT ha recentemente acquisito nuovi strumenti per aumentare l'accuratezza, l'affidabilità e la capacità di produzione di dati di sequenziamento, tra questi spicca l'ultimo e più potente sequenziatore di Illumina, NovaSeq X Plus , con una capacità produttiva di 120Tb/mese .
Per informazioni scrivi a next@crs4.it
Contattaci!
Servizi disponibili su NovaSeq X Plus preparazione librerie + sequenziamento+ analisi bioinformatiche + storage
RNA Seq
(~ 100 M Paired-end Reads)
TruSeq Stranded Total RNA Library Prep Gold
Illumina Stranded Total RNA Prep, Ligation with Ribo-Zero Plus
TruSeq Stranded mRNA Library Prep
Illumina Stranded mRNA Prep, Ligation
Whole Genome Sequencing Human | Animal | Plant | Microbial
WGS (~ 120 Gb = Coverage 30X)
Illumina DNA LP (M) Tagmentation
KAPA HyperPlus kit
IDT UD Index
I protocolli di preparazione delle librerie possono essere personalizzati in base alle specifiche esigenze.
Whole Exome Sequencing Human | Animal | Plant | Microbial
WES (~ 15 Gb = Coverage 100X)
Agilent SureSelect Human All ExonI protocolli di preparazione delle librerie possono essere personalizzati in base alle specifiche esigenze.
miRNA Seq
(~ 10 M Single Reads)
QIAseq miRNA Library Kit
UDI
UMI
Ulteriori servizi disponibili
Metagenomics
On MiSeq
Metagenomic analysis for 16S rRNA gene
Microbial Genome Resequencing,Custom Panels and Protocols
On NovaSeq X Plus | On MiSeq
I protocolli di preparazione delle librerie per WGS , WES e Trascrittoma possono essere personalizzati per soddisfare requisiti specifici.
Tipizzazione genica HLA ad alta risoluzione fino al sesto digit
Per pannelli genici e altri protocolli specifici , contattateci
Sequencing only
On NovaSeq X Plus - flow cell 10B:
2 × 50 /100 /150 bp; ~1 Tb / ~2 Tb / ~3 Tb
On MiSeq - MiSeq Reagent Kit:
v3 (150/600-cycles); ~23 MCluster; ~3,5/~14 Gb
v2 (300/500-cycles); ~13 MCluster; ~4,5/~8 Gb
v2 Micro (300-cycles); ~4 MCluster; ~1 Gb
v2 Nano (300/500-cycles); ~1 MCluster; ~300/~500 Mb
Servizi custom
Nella nostra sede o da remoto
La nostra piattaforma è in grado di fornire servizi NGS personalizzati , progettati sulla base delle esigenze del cliente .
Inoltre, offriamo servizi di consulenza e di alta formazione , sia da remoto che direttamente nel nostro laboratorio.
Diventa partner CRS4
La nostra piattaforma di Next Generation Sequencing è a disposizione della comunità scientifica per collaborazioni in progetti di ricerca Per qualsiasi informazione non esitare a contattarci next@crs4.it
IL LABORATORIO NGS
Il nostro laboratorio è stato un pioniere nell'uso della tecnologia NGS, a partire dal 2009 con due Genome Analyzer, i primi sequenziatori prodotti da Illumina. Nel 2010 sono stati acquisiti tre sequenziatori HiSeq2000 e successivamente un HiSeq3000.15 anni di esperienza sono stati applicati decine di diversi protocolli per l'elaborazione di migliaia di campioni di vario tipo e provenienza .
Recenti acquisizioni
Illumina NovaSeq X Plus l'ultimo e più potente sequenziatore di Illumina, con una capacità produttiva di 120Tb/mese Agilent Fragment Analyzer 5300 , Elettroforesi capillare (48 capillari) per l’analisi di frammenti e il controllo della qualità degli acidi nucleici
Tecan Infinite 200 Pro, Plate Reader per la quantificazione in fluorescenza degli acidi nucleici e delle librerie Illumina MiSeq, sequenziatore per metagenomica, small panels e altri protocolli personalizzati. Hamilton NGS STAR, Liquid Handler per la preparazione delle librerie con velocità di elaborazione fino a 96 librerie di campioni elaborate contemporaneamente. La piattaforma NEXT è direttamente interconnessa con le risorse HPC del centro di calcolo del CRS4 , un'infrastruttura unica in Italia che permette di caratterizzare progetti di sequenziamento su larga scala.database accessibile via web , integrato con un sistema LIMS (Laboratory Information Management System) e a un sistema di gestione delle pipeline di analisi. La piattaforma è progettata per consentire agli utenti della struttura di richiedere analisi, eseguire indagini personalizzate e organizzare, consultare e aggiornare i dati relativi ai loro progetti.
Settori di interesse
Sequenziamento del genoma umano o di un insieme di geni specifici per l'indagine di un'ampia gamma di variazioni del DNA che possono essere causali o predisponenti a malattie, o coinvolte nella modulazione della risposta ai farmaci; analisi del trascrittoma (RNASeq) per evidenziare variazioni nell'espressione genica; tipizzazione genica HLA ad alta risoluzione con eliminazione delle ambiguità; caratterizzazione del microbiota per identificare gli agenti patogeni; caratterizzazione dei genomi di patogeni batterici e virali per studi epidemiologici o per comprendere i meccanismi di resistenza ai farmaci e virulenza.
Le informazioni sul genoma completo di più specie animali e vegetali caratterizzano la selezione di ceppi più produttivi e resistenti alle malattie e la loro tracciabilità geografica; analisi del metagenoma del DNA ambientale nelle catene di produzione agroalimentare per l'individuazione di specie contaminanti (virus, batteri, funghi e parassiti, animali e piante) o l'identificazione di patogeni che influenzano la produttività delle colture o del bestiame; autenticazione delle specie per il controllo delle frodi alimentari; individuazione di OGM non autorizzati nei prodotti alimentari; indagini di epidemiologia molecolare nei casi di malattie di origine alimentare.
La tecnologia facilita la scoperta di nuovi agenti patogeni (batteri, virus e funghi) indipendentemente dalla coltura in vitro e dalla conoscenza delle caratteristiche genotipiche o fenotipiche; caratterizzazione completa del genoma di microrganismi specifici, isolati o provenienti da un campione misto; screening ad alto rendimento, utile per le indagini epidemiologiche.
Questa tecnologia all'avanguardia, grazie alle sue capacità di analisi, più sensibili e ad ampio spettro, consente di indagare simultaneamente un numero considerevole di regioni polimorfiche del DNA per l'identificazione di un individuo, l'inferenza delle caratteristiche fenotipiche (colore dell'iride, colore dei capelli, carnagione, altezza, età, predisposizione alla calvizie e morfologia del viso) e dell'origine geografica. Inoltre, nei casi in cui il campione sia degradato, l'analisi del genoma mitocondriale completo fornisce informazioni utili per l'identificazione dell'individuo.
IL NOSTRO TEAM Roberto Cusano
BiotecnologoResponsabile del Next Lab –
Gessica Milia
BiologaRicercatrice –
Rossano Atzeni
BioinformaticoRicercatore –
Lidia Leoni
Direttrice del Settore Biosciences and Computational Infrastructures, Smart Projects and Quantum Computing
Ultime pubblicazioni
The double-sided of human leukocyte antigen-G molecules in type 1 autoimmune hepatitis Cusano Roberto , Giglio Sabrina
A Multigene-Panel Study Identifies Single Nucleotide Polymorphisms Associated with Prostate Cancer Risk Cusano Roberto , Sechi Leonardo
Circulating Levels of miRNAs from 320 Family in Subjects with Lipodystrophy: Disclosing Novel Signatures of the Disease Cusano Roberto , Massidda Matteo , Montanelli Lucia, Gilio Donatella, Gatti Gianluca, Giacomina Alessandro, Costa Mario, Santini Ferruccio, Maffei Margherita
Next Generation Sequencing for miRNA Detection on the Exhaled Breath Condensate: A Pilot Study Cusano Roberto , Ferrari Paolo Albino, Massidda Matteo , Fotia Giorgio , De Matteis Sara, Cocco Pierluigi
mRNA-miRNA networks identify metabolic pathways associated to the anti-tumorigenic effect of thyroid hormone on preneoplastic nodules and hepatocellular carcinoma Cusano Roberto , Kowalik Marta Anna
Genomic Snapshot of SARS-CoV-2 in Migrants Entering Through Mediterranean Sea Routes Cusano Roberto , Rubino Salvatore
Contattaci
Per ospedali, IRCSS, università e centri di ricerca interessati a instaurare una collaborazione con il CRS4, si consiglia di scrivere a: roberto.cusano@crs4.it
Per richieste, preventivi e qualsiasi altra informazione, compilare il modulo sottostante. Vi risponderemo al più presto.
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Illumina NovaSeq X Plus l'ultimo e più potente sequenziatore di Illumina, con una capacità produttiva di 120Tb/mese 
Agilent Fragment Analyzer 5300, Elettroforesi capillare (48 capillari) per l’analisi di frammenti e il controllo della qualità degli acidi nucleici
Tecan Infinite 200 Pro, Plate Reader per la quantificazione in fluorescenza degli acidi nucleici e delle librerie 
Illumina MiSeq, sequenziatore per metagenomica, small panels e altri protocolli personalizzati. 
Hamilton NGS STAR, Liquid Handler per la preparazione delle librerie con velocità di elaborazione fino a 96 librerie di campioni elaborate contemporaneamente. 
